The choice of mobile phase content in both enantioselective high-performance liquid chromatography (HPLC) and supercritical fluid chromatography (SFC) has expanded dramatically to a great variety of organic solvents due to the stability of the immobilized polysaccharide phases. By using practically any organic solvent in conjunction with three immobilized chiral stationary phases (CSPs) — CHIRALPAK IA, IB or IC — chemists can maximize success rates in compound screening for identifying an effective separation of chiral molecules by enantioselective HPLC and SFC.

Additionally, immobilized column selectivities are complementary to those of coated polysaccharide-based CSPs, leading to a high degree of success in screening for a successful separation method using the available coated phases in a combination with CHIRALPAK IA, IB and IC.

The immobilized columns have been successfully employed in pharmaceutical research and development applications. The advent of CHIRALPAK IA, IB and IC offers enhanced compound solubility, greater column stability and novel column selectivity, all of which improve column lifetime.

For more information about immobilized CSPs for the North American market from Chiral Technologies, Inc. visit http://www.chiraltech.com/col_csp.asp. For more information about immobilised CSPs for the European market from Chiral Technologies Europe, visit http://www.chiral.fr/new_immobilised_chiralpak.asp.